1Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, China 2Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China 3State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China 4Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada *Correspondence to:Chunfu Zheng , Email:zheng.alan@hotmail.com